연예인 2011. 8. 26. 20:24

Prof. Sir Alec John Jeffreys

Prof. Sir Alec John Jeffreys, FRS (born 9 January 1950 in Oxford, Oxfordshire, England) is a British geneticist, who developed techniques for DNA fingerprinting and DNA profiling which are now used all over the world in forensic science to assist police detective work, and also to resolve paternity and immigration disputes. He is a professor of genetics at the University of Leicester, and he became an honorary freeman of the City of Leicester on 26 November 1992. In 1994, he was knighted by her Majesty Queen Elizabeth II of the United Kingdom, for Services to Science and Technology. Genetic fingerprinting Jeffreys had a "eureka moment" in his lab in Leicester after looking at the X-ray film image of a DNA experiment at 9:05 am on Monday 10 September 1984, which unexpectedly showed both similarities and differences between the DNA of different members of his technician's family. Within about half an hour, he realized the possible scope of DNA fingerprinting, which uses variations in the genetic code to identify individuals. The method has become important in forensic science to assist police detective work, and it has also proved useful in resolving paternity and immigration disputes.The method can also be applied to non-human species, for example in wildlife population genetics studies. Before his methods were commercialised in 1987 his laboratory was the only centre carrying out DNA fingerprinting in the world, and during this period of about two or three years it was very busy, receiving inquiries from all over the globe. Jeffreys' DNA method, which is often called DNA fingerprinting, was first put to use when he was asked to help in a disputed immigration case to confirm the identity of a British boy whose family was originally from Ghana.The case was resolved when the DNA results proved that the boy was closely related to the other members of the family, and Jeffreys saw the relief in the mother's face when she heard the results. DNA fingerprinting was first used as a police forensic test to identify the rapist and killer of two teenagers, Lynda Mann and Dawn Ashworth, who were both murdered in Narborough, Leicestershire, in 1983 and 1986 respectively. Colin Pitchfork was identified and convicted of murder after samples taken from him matched semen samples taken from the two dead girls. This turned out to be a specifically important identification for without it, British Authorities believe that Richard Buckland, the main suspect, would have inevitably been convicted. Therefore, not only did Jeffrey's work in this case prove who the real killer was, but exonerate someone who likely would have spent his life in prison otherwise. In 1992, Jeffreys' methods were used to confirm the identity for German prosecutors of the Nazi Dr. Josef Mengele, who had died in 1979, by comparing DNA obtained from a femur bone of his exhumed skeleton, and DNA from his widow and son, in a similar way to paternity testing. DNA profiling DNA profiling based on typing individual highly variable minisatellites in the human genome was also developed by Alec Jeffreys and his team in 1985, with the term DNA fingerprinting being retained for the initial test that types many minisatellites simultaneously. By focussing on just a few of these highly variable minisatellites, DNA profiling made the system more sensitive, more reproducible, and amenable to computer databasing, and soon became the standard forensic DNA system used in criminal case work and paternity testing worldwide. The development of DNA amplification by the Polymerase Chain Reaction (PCR) opened up new approaches to forensic DNA testing, allowing automation, greatly increased sensitivity and a move to alternative marker systems. The most commonly used markers are now variable microsatellites, also known as Short Tandem Repeats (STRs), that Jeffreys first exploited in 1990 in the Joseph Mengele case. STR profiling was further refined by a team of scientists led by Peter Gill at the Forensic Science Service in the 1990s, allowing the launch of the UK National DNA Database (NDNAD) in 1995. With highly automated and sophisticated equipment, modern-day DNA profiling can process hundreds of samples each day. Ten microsatellites plus a marker for sex determination are used with the current system developed for the NDNAD, giving a discrimination power of one in over a billion. Under British law, anyone arrested in England, Wales or Northern Ireland has their DNA profile taken and stored on the database whether or not they are convicted (different rules apply in Scotland). The national database now contains the DNA information of nearly five million people. Jeffreys has opposed the current use of DNA profiling, where the government has access to that database, and has instead proposed a database of all people's DNA, whose access would be controlled by an independent third party.http://www.firstnamestore.com/?p=21773

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연예인 2011. 8. 26. 20:21

Alfred Bernhard Nobel

Alfred Bernhard Nobel ( pronunciation (help·info)) (21 October 1833 – 10 December 1896) was a Swedish chemist, engineer, innovator, and armaments manufacturer. He is the inventor of dynamite. Nobel also owned Bofors, which he had redirected from its previous role as primarily an iron and steel producer to a major manufacturer of cannon and other armaments. Nobel held 355 different patents, dynamite being the most famous. In his last will, he used his enormous fortune to institute the Nobel Prizes. The synthetic element nobelium was named after him. Nobel found that when nitroglycerin was incorporated in an absorbent inert substance like kieselguhr (diatomaceous earth) it became safer and more convenient to handle, and this mixture he patented in 1867 as 'dynamite'. Nobel demonstrated his explosive for the first time that year, at a quarry in Redhill, Surrey, England. In order to help reestablish his name and improve the image of his business from the earlier controversies associated with the dangerous explosives, Nobel had also considered naming the highly powerful substance "Nobel's Safety Powder", but settled with Dynamite instead, referring to the Greek word for 'power'. Nobel later on combined nitroglycerin with various nitrocellulose compounds, similar to collodion, but settled on a more efficient recipe combining another nitrate explosive, and obtained a transparent, jelly-like substance, which was a more powerful explosive than dynamite. 'Gelignite', or blasting gelatin, as it was named, was patented in 1876; and was followed by a host of similar combinations, modified by the addition of potassium nitrate and various other substances. Gelignite was more stable, transportable and conveniently formed to fit into bored holes, like those used in drilling and mining, than the previously used compounds and was adopted as the standard technology for mining in the Age of Engineering bringing Nobel a great amount of financial success, though at a significant cost to his health. An off-shoot of this research resulted in Nobel's invention of ballistite, the precusor of many modern smokeless powder explosives and still used as a rocket propellant. Nobel, Alfred Bernhard in the 1911 Encyclopædia Britannica

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